生物
系统发育树
适应(眼睛)
谱系(遗传)
密码子使用偏好性
基因
宿主适应
遗传学
进化生物学
冠状病毒
自然选择
病毒学
选择(遗传算法)
2019年冠状病毒病(COVID-19)
疾病
基因组
传染病(医学专业)
神经科学
人工智能
计算机科学
医学
病理
作者
Qi Peng,Xue Zhang,Jizong Li,Wenlong He,Baochao Fan,Yanxiu Ni,Maojun Liu,Bin Li
摘要
The porcine deltacoronavirus (PDCoV) is a newly discovered pig enteric coronavirus that can infect cells from various species. In Haiti, PDCoV infections in children with acute undifferentiated febrile fever were recently reported. Considering the great potential of interspecies transmission of PDCoV, we performed a comprehensive analysis of codon usage patterns and host adaptation profiles of 54 representative PDCoV strains with the spike (S) gene. Phylogenetic analysis of the PDCoV S gene indicates the PDCoV strains can be divided into five genogroups. We found a certain codon usage bias existed in the S gene, in which the synonymous codons are often ended with U or A. Heat map analysis revealed that all the PDCoV strains shared a similar codon usage trend. The PDCoV S gene with a dN / dS value lower than 1 reveals a negative selection on the PDCoV S gene. Neutrality analysis showed that natural selection is the dominant force in shaping the codon usage bias of the PDCoV S gene. Unexpectedly, host adaptation analysis reveals a higher adaptation level of PDCoV to Homo sapiens and Gallus gallus than to Sus scrofa. Compared to the USA lineage, the PDCoV strains in the Early China lineage and Thailand lineage were less adapted to their hosts, which indicates that the evolutionary process plays an important role in the adaptation ability of PDCoV. These findings of this study add to our understanding of PDCoV's evolution, adaptability, and interspecies transmission. This article is protected by copyright. All rights reserved
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