Gait regulation of hindlimb based on central pattern generator in rats with a spinal cord injury

后肢 脊髓损伤 脊髓 中心图形发生器 医学 神经科学 步态 物理医学与康复 解剖 生物 内科学 节奏
作者
Xiaoyan Shen,Xiongjie Lou,Wei Shao,Zhiling Li,Yan Wu,Song Lu
出处
期刊:Proceedings Of The Institution Of Mechanical Engineers, Part H: Journal Of Engineering In Medicine [SAGE Publishing]
卷期号:236 (7): 979-987
标识
DOI:10.1177/09544119221095341
摘要

A spinal stimulator that can regulate hindlimb movements using monopolar stimulation has not been developed yet. Nevertheless, in a previous study, we found a specific central pattern generator site on the right side of the rat spinal cord. By stimulating these sites with certain pulse signals, the alternating movement of the hindlimb can be obtained using fewer electrodes. Therefore, in this research, considering the specific central pattern generator site as the target, functional electrical stimulation was performed on rats with spinal cord injury using monopolar stimulation. Angle sensors were used to track and capture the knee joint angle data of the right hindlimb; thus, the mapping relationship between the voltage amplitude and the knee angle parameters was established. Based on this relationship, the rats' hindlimb were controlled. Compared with the traditional spinal stimulator, the proposed approach increases the gait feedback, requires fewer electrodes, and simplifies the timing of stimulation. The rats with spinal cord injury were subjected to stimulation training for half an hour every day for 28 consecutive days. The Basso, Beattie and Bresnahan score showed that 76% of the health level could be achieved on the 28th day. Finally, somatosensory evoked potential analysis showed that the measurement results were close to the standard value on the 28th day. This study lays a foundation for future rehabilitation research on the hindlimb.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Rondab应助卡卡罗特采纳,获得10
1秒前
5秒前
9秒前
10秒前
芋孟齐发布了新的文献求助10
10秒前
14秒前
14秒前
一路生花完成签到,获得积分10
14秒前
orixero应助小慧儿采纳,获得10
14秒前
Ava应助科研通管家采纳,获得10
14秒前
14秒前
SYLH应助科研通管家采纳,获得10
14秒前
田様应助科研通管家采纳,获得10
15秒前
丘比特应助科研通管家采纳,获得10
15秒前
潇湘雪月发布了新的文献求助10
15秒前
今后应助科研通管家采纳,获得10
15秒前
科研通AI2S应助科研通管家采纳,获得10
15秒前
情怀应助科研通管家采纳,获得10
15秒前
打打应助科研通管家采纳,获得10
15秒前
15秒前
香蕉觅云应助科研通管家采纳,获得10
15秒前
15秒前
斯文败类应助科研通管家采纳,获得10
15秒前
wanci应助科研通管家采纳,获得10
15秒前
15秒前
爆米花应助科研通管家采纳,获得10
15秒前
SYLH应助科研通管家采纳,获得30
15秒前
星辰大海应助科研通管家采纳,获得10
15秒前
栗惠完成签到 ,获得积分20
15秒前
星辰大海应助科研通管家采纳,获得10
15秒前
李爱国应助科研通管家采纳,获得10
15秒前
猪猪hero发布了新的文献求助10
16秒前
科目三应助科研通管家采纳,获得10
16秒前
16秒前
16秒前
Bob完成签到,获得积分10
16秒前
19秒前
20秒前
20秒前
20秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989242
求助须知:如何正确求助?哪些是违规求助? 3531393
关于积分的说明 11253753
捐赠科研通 3270010
什么是DOI,文献DOI怎么找? 1804868
邀请新用户注册赠送积分活动 882084
科研通“疑难数据库(出版商)”最低求助积分说明 809136