Can betamethasone prevent Nicolau syndrome when coadministered with penicillin? A case report

Abstract We present a 33‐year‐old female patient with Nicolau syndrome (NS) who received one injection of benzathine penicillin and one injection of betamethasone to the right buttock, and one injection of benzathine penicillin to the left. NS was seen only in the left buttock, where it was intramuscularly injected with penicillin benzathine alone.