Recent emergence of the SARS-CoV-2 variant as OMICRON has become a global concern. This short note highlights the identification and global spread of OMICRON which has occupied more than 77 nations by now, which resulted in many hypotheses about its origin and degree of infectivity. The detection of mutations in the RBD region of Spike protein is a concern by passing vaccine immunity. The ahead will speak about its transmission potentiality, infectivity, disease morbidity or mortality as well as its effect on COVID-19 vaccines. This article is protected by copyright. All rights reserved.