姜黄素
姜黄
药理学
光动力疗法
姜黄素
癌症
生物利用度
药代动力学
白藜芦醇
医学
化学
癌症研究
传统医学
内科学
有机化学
作者
Liguo Xie,Xiuling Ji,Qi Zhang,Yunlin Wei
标识
DOI:10.1016/j.biopha.2021.112567
摘要
Curcumin, a phytochemical derived from the rhizome of turmeric (Curcuma longa L.), has a broad group of substances with antibacterial, anti-inflammatory, anti-oxidant, anticancer activities. The anticancer activity of curcumin and its derivatives are mainly related to its regulation of signal transduction pathways. However, due to the low oral availability of curcumin, fast metabolism and other pharmacokinetic properties limit the application of curcumin in the treatment of cancer. Evidence suggests that curcumin combined with photodynamic therapy can overcome the limitation of curcumin's low bioavailability by acting on apoptosis pathways, such as B-cell lymphoma 2 (Bcl-2) and caspase family, and affecting cell cycle. This paper reviews the structure and pharmacokinetics of curcumin, focusing on the anticancer activity of curcumin combined with photodynamic therapy and the effects on cancer-related signal pathways.
科研通智能强力驱动
Strongly Powered by AbleSci AI