阿霉素
膀胱癌
纤维连接蛋白
肽
癌症研究
生物材料
医学
纳米颗粒
泌尿科
癌症
外科
化学
生物医学工程
化疗
内科学
材料科学
纳米技术
生物化学
细胞外基质
作者
Jiaqi Wang,Pei‐Pei Yang,Da‐Yong Hou,Ya-Qiong Yan,Kai Yue,Weishen Zhong,Ting Xiao,Xiu‐Hai Wu,Ziqi Wang,Peng Wu,Lei Wang,Hao Wang,Wanhai Xu
出处
期刊:Nano Today
[Elsevier]
日期:2022-07-13
卷期号:45: 101551-101551
被引量:13
标识
DOI:10.1016/j.nantod.2022.101551
摘要
The regrowth of residual tumor left by incomplete surgery leads to bladder cancer recurrence. Postoperative intravesical instillation in clinic shows unsatisfactory recurrence inhibition owing to rapid drug emptying and non-specific distribution. Here, inspired by intrinsic bacterial adhesion towards exposed wounds through fibronectin binding peptide, we develop a bacteria-inspired peptide-based nanoparticle that targets exposed fibronectin on the surgical bed with residual tumor. Upon binding, the nanoparticle simultaneously transforms into fibrous coating as drug depots for long-term release of encapsulated doxorubicin. The transformable nanoparticle retains 8.5-fold higher doxorubicin concentration than free one in bladders of live mice 3 days post-instillation. Reasonably, this formulation obviously suppresses tumor regrowth in an incomplete tumor resection model. Compared to the clinical doxorubicin treatment, it reduces the recurrence rate from 71% to 29% in a murine orthotopic bladder cancer model. This bacteria-inspired biomaterial provides a promising intravesical treatment but also opportunities for clinical management on cancer recurrence.
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