骨重建
医学
骨质疏松症
骨矿物
糖尿病
内科学
内分泌学
骨折
2型糖尿病
代谢性骨病
放射科
作者
Bingzi Dong,Ruolin Lv,Jun Wang,Lin Che,Zhongchao Wang,Zhouyang Huai,Yangang Wang,Lili Xu
标识
DOI:10.3389/fendo.2022.918350
摘要
Type 2 diabetes mellitus (T2DM) is a risk factor for osteoporosis. The effects of T2DM and anti-diabetic agents on bone and mineral metabolism have been observed. Sodium–glucose co-transporter 2 inhibitors (SGLT-2is) promote urinary glucose excretion, reduce blood glucose level, and improve the cardiovascular and diabetic nephropathy outcomes. In this review, we focused on the extraglycemic effect and physiological regulation of SGLT-2is on bone and mineral metabolism. SGLT-2is affect the bone turnover, microarchitecture, and bone strength indirectly. Clinical evidence of a meta-analysis showed that SGLT-2is might not increase the risk of bone fracture. The effect of SGLT-2is on bone fracture is controversial, and further investigation from a real-world study is needed. Based on its significant benefit on cardiovascular and chronic kidney disease (CKD) outcomes, SGLT-2is are an outstanding choice. Bone mineral density (BMD) and fracture risk evaluation should be considered for patients with a high risk of bone fracture.
科研通智能强力驱动
Strongly Powered by AbleSci AI