ANRORCRearrangement

Abstract ANRORC rearrangement is a very common transformation for heterocycles, and has been discovered for more than a century already. It occurs in nucleophilic substitution of heterocyclic compounds, and stands for a whole process of the initial addition of a nucleophile, followed by the ring opening and ring closure during the substitution. This transformation is also known as S N (ANRORC) reaction or degenerate ring transformation. This reaction has been reported to consist two subgroups with either an “outside” leaving group or “inside” leaving group. This rearrangement reaction has wide applications in heterocycle chemistry.