Nanocarrier-based dermopharmaceutical formulations for the topical management of atopic dermatitis

纳米载体 特应性皮炎 固体脂质纳米粒 医学 不利影响 脂质体 生物利用度 耐受性 药品 药物输送 皮肤病科 药理学 纳米技术 材料科学
作者
Ana Cláudia Paiva‐Santos,Melissa Gama,Diana Peixoto,Inês Sousa-Oliveira,Inês Ferreira-Faria,Mahdi Zeinali,Soheil Abbaspour‐Ravasjani,Filipa Mascarenhas-Melo,Hamed Hamishehkar,Francisco Veiga
出处
期刊:International Journal of Pharmaceutics [Elsevier BV]
卷期号:618: 121656-121656 被引量:30
标识
DOI:10.1016/j.ijpharm.2022.121656
摘要

Atopic dermatitis (AD) is a chronic disease that affects the skin, and that is characterized by highly itchy inflammation, frequent eczematous lesions, and a fluctuating course. The current treatment consists of a multi-stage approach that aims to establish persistent disease control towards the improvement of the quality of life of the patients. Topical therapy is the basis of AD treatment, however, due to the difficulty of crossing the skin barrier, topical application of drugs remains a challenge. In fact, in addition to the low skin bioavailability, and limited accessibility to deeper skin of the drugs - due to difficulty in penetrating the epidermis - implemented drugs in the clinical are associated with serious adverse effects, which are responsible for safety and efficacy limitations, leading to a reduction in patients' compliance. Nanotechnology arises as an emerging approach for the treatment of AD, allowing for controlled release, targeted delivery, improved penetration, and bioavailability of drugs assets, resulting in marked improved therapeutic efficacy and reduction of adverse effects. Although its promising outputs, additional studies are needed to recognize the toxicological characteristics, cost-benefit, and long-term safety of nanocarriers applied to this end. Advanced drug delivery systems, particularly nanoemulsions, liposomes, ethosomes, transfersomes, solid lipid nanoparticles, nanostructured lipid carriers, nanocrystals, polymeric nanoparticles, and polymeric micelles have been used, and are thoroughly addressed in this review as promising nanoformulations towards the topical treatment of AD.
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