Nanocarrier-based dermopharmaceutical formulations for the topical management of atopic dermatitis

纳米载体 特应性皮炎 固体脂质纳米粒 医学 不利影响 脂质体 生物利用度 耐受性 药品 药物输送 皮肤病科 药理学 纳米技术 材料科学
作者
Ana Cláudia Paiva‐Santos,Melissa Gama,Diana Peixoto,Inês Sousa-Oliveira,Inês Ferreira-Faria,Mahdi Zeinali,Soheil Abbaspour‐Ravasjani,Filipa Mascarenhas-Melo,Hamed Hamishehkar,Francisco Veiga
出处
期刊:International Journal of Pharmaceutics [Elsevier BV]
卷期号:618: 121656-121656 被引量:30
标识
DOI:10.1016/j.ijpharm.2022.121656
摘要

Atopic dermatitis (AD) is a chronic disease that affects the skin, and that is characterized by highly itchy inflammation, frequent eczematous lesions, and a fluctuating course. The current treatment consists of a multi-stage approach that aims to establish persistent disease control towards the improvement of the quality of life of the patients. Topical therapy is the basis of AD treatment, however, due to the difficulty of crossing the skin barrier, topical application of drugs remains a challenge. In fact, in addition to the low skin bioavailability, and limited accessibility to deeper skin of the drugs - due to difficulty in penetrating the epidermis - implemented drugs in the clinical are associated with serious adverse effects, which are responsible for safety and efficacy limitations, leading to a reduction in patients' compliance. Nanotechnology arises as an emerging approach for the treatment of AD, allowing for controlled release, targeted delivery, improved penetration, and bioavailability of drugs assets, resulting in marked improved therapeutic efficacy and reduction of adverse effects. Although its promising outputs, additional studies are needed to recognize the toxicological characteristics, cost-benefit, and long-term safety of nanocarriers applied to this end. Advanced drug delivery systems, particularly nanoemulsions, liposomes, ethosomes, transfersomes, solid lipid nanoparticles, nanostructured lipid carriers, nanocrystals, polymeric nanoparticles, and polymeric micelles have been used, and are thoroughly addressed in this review as promising nanoformulations towards the topical treatment of AD.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
香蕉初瑶完成签到,获得积分10
刚刚
meimei完成签到 ,获得积分10
刚刚
儒雅的菠萝吹雪完成签到,获得积分10
1秒前
1秒前
2秒前
水寒完成签到,获得积分10
2秒前
拉长的念珍完成签到,获得积分10
3秒前
大气夜山完成签到 ,获得积分10
3秒前
Tristan完成签到 ,获得积分10
5秒前
我思故我在完成签到,获得积分10
5秒前
6秒前
何浏亮完成签到,获得积分10
7秒前
阿成完成签到,获得积分10
7秒前
Pauline完成签到 ,获得积分10
7秒前
8秒前
微笑的语芙完成签到,获得积分10
8秒前
8秒前
小背包完成签到 ,获得积分10
8秒前
水寒发布了新的文献求助10
10秒前
希望天下0贩的0应助17采纳,获得10
10秒前
yu完成签到 ,获得积分10
10秒前
钟瑞乾完成签到,获得积分10
10秒前
花痴的电灯泡完成签到,获得积分10
11秒前
虚心念桃完成签到,获得积分10
12秒前
jiaolulu发布了新的文献求助10
13秒前
zyw完成签到 ,获得积分10
13秒前
ironsilica完成签到,获得积分10
16秒前
17秒前
被动科研完成签到,获得积分10
19秒前
斗牛的番茄完成签到 ,获得积分10
20秒前
所所应助时尚俊驰采纳,获得10
20秒前
zgt01发布了新的文献求助10
24秒前
背后如彤完成签到 ,获得积分10
26秒前
27秒前
通通通完成签到,获得积分10
28秒前
李治海完成签到,获得积分10
28秒前
诸葛烤鸭完成签到,获得积分10
28秒前
君君完成签到 ,获得积分10
29秒前
long0809完成签到,获得积分10
29秒前
勤劳寒烟完成签到,获得积分10
31秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038235
求助须知:如何正确求助?哪些是违规求助? 3575992
关于积分的说明 11374009
捐赠科研通 3305760
什么是DOI,文献DOI怎么找? 1819276
邀请新用户注册赠送积分活动 892662
科研通“疑难数据库(出版商)”最低求助积分说明 815022