甲基化
RNA甲基化
N6-甲基腺苷
骨重建
骨质疏松症
生物
DNA甲基化
翻译(生物学)
核糖核酸
生物信息学
细胞生物学
计算生物学
癌症研究
信使核糖核酸
基因
基因表达
遗传学
内分泌学
甲基转移酶
作者
Yuan Li,Meng Li,Baobing Zhao
标识
DOI:10.1016/j.pharmthera.2022.108174
摘要
N6-methyladenosine (m6A), a novel epitranscriptomic RNA modification, plays crucial roles in a variety of biological processes and diseases. Recently, there are growing evidence supporting that m6A methylation is essential for bone development and homeostasis through the regulation of key genes by regulating RNA stability, localization, turnover and translation efficiency. In this review, we summarized our current understanding of the functional roles of m6A methylation and its related regulators in bone development and bone remodeling. These findings will offer new directions and insights on the further investigations of m6A methylation in bone biology. Moreover, we also discussed important advances of m6A methylation related regulators as potential therapeutic targets, which allows for novel therapeutic strategies on the medications of bone-related diseases including osteoporosis.
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