原子经济
异构化
Atom(片上系统)
试剂
化学
组合化学
有机化学
计算机科学
催化作用
嵌入式系统
作者
Xiao Xiao,Hongyu Tian,Yin-Qiu Huang,Yin‐Jie Lu,Jingjie Fang,Gao-Jie Zhou,Fen‐Er Chen
摘要
A new type of organocatalyzed 1,3-thiosulfonylation has been developed to straightforwardly access highly functionalized vinyl sulfones, which features mild conditions, atom- and step-economy, practicability, conciseness, and environmental friendliness. Moreover, these valuable products can be transformed to vinyl sulfides via a base-promoted isomerization. The versatile route can efficiently and rapidly introduce SCD3 groups with excellent levels of deuterium content (>99% D) by utilizing our newly developed SCD3 reagents. Gram-scale operations and further transformations are smoothly carried out, providing promising applications for drug discovery.
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