适体
DNA
共轭体系
药物输送
靶向给药
共价键
化学
药品
组合化学
阿霉素
纳米技术
分子生物学
药理学
生物化学
生物
材料科学
遗传学
有机化学
化疗
聚合物
作者
Runze Li,Xiaohui Wu,Jing Li,Xuehe Lu,Robert Chunhua Zhao,Jianbing Liu,Baoquan Ding
出处
期刊:Nanoscale
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:14 (26): 9369-9378
被引量:9
摘要
Targeted delivery of therapeutic drugs is essential for precise treatment of various diseases to reduce possible serious side-effects. A screened DNA aptamer has been widely developed for active targeting delivery. Herein, we report a facile strategy for the construction of a branched DNA aptamer cluster-based nanoplatform for efficiently targeted drug delivery. In our design, the terminal-modified DNA aptamer can be covalently conjugated to form a branched aptamer cluster by click reaction easily. The branched aptamer cluster-modified DNA tetrahedron (TET) demonstrates highly targeted cellular uptake with the modification of only one site. After loading the chemotherapeutic drug (doxorubicin, DOX), the DNA aptamer cluster-based nanoplatform elicits a remarkable and selective inhibition of tumor cell proliferation by much-enhanced targeted delivery. This covalently conjugated branched DNA aptamer cluster-based nanoplatform provides a new strategy for the development of targeted drug delivery.
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