Bone-targeted biomaterials: Strategies and applications

Bone diseases including osteoarthritis, osteoporosis, and bone tumors are becoming severe threats to public health. Bone-targeted biomaterials-based strategies could improve therapeutic effects while avoiding systemic complications, demonstrating promising translational potential in bone-related diseases treatment. In the present review, we introduced the bone biology, bone-targeting strategies, bone-targeted moieties, and bone-targeted biomaterials for the treatment of bone diseases. The discussions herein presented will provide useful information of bone-targeted biomaterials for the chemists and materials scientists, give clue for the selection of suitable bone-targeted drug for the pharmacists, and offer new insights into the therapy of bone-related diseases for the clinicians.