化学
亚胺
转移加氢
有机化学
氢
酒
药物化学
组合化学
催化作用
钌
作者
Gaolin Li,Meichen Li,Zhenhai Xia,Ze Tan,Wei Deng,Fang Chen
标识
DOI:10.1021/acs.joc.2c00402
摘要
Meerwein-Ponndorf-Verley (MPV)-type reduction between benzonitriles and benzylic alcohols under transition-metal-free conditions has been demonstrated for the first time. Using simple KOt-Bu as the base, various benzonitriles can be efficiently reduced by benzylic alcohols via hydrogen transfer reduction, and the resultant phenyl imine can react further with benzylic alcohols to give amides as the final product in which both the alcohols and the nitriles are incorporated. Preliminary mechanistic investigations indicated that the reaction may go through multiple MPV-type hydrogen transfer processes.
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