材料科学
生物相容性
结晶度
复合数
明胶
钛
化学工程
成骨细胞
脚手架
锶
骨生长
核化学
生物医学工程
复合材料
体外
化学
冶金
有机化学
生物化学
工程类
内科学
医学
作者
Shihong Li,Yang He,Jian Li,Jun Sheng,Shiwei Long,Zhiqiang Li,Bo-Bo Jiang,Hong En Fu,Jie Weng,Juan Wu,Wei Zheng
标识
DOI:10.1177/08853282221080525
摘要
Co-doping of multiple ions can effectively adjust the biological properties of hydroxyapatite (HA) for various biomedical applications. In this study, we prepared Sr 2+ and Cu 2+ double-doped hollow HA and characterized them by SEM, EDS, XRD, FTIR, and other methods. We found that Sr 2+ and Cu 2+ were uniformly distributed in the hollow carbonic acid HA microspheres. As the proportion of metal elements increases, the microspherical appearance and crystallinity properties also change. In addition, we also prepared porous titanium scaffolds through 3D printing technology and constructed composite scaffolds of porous titanium scaffolds, Sr 2+ and Cu 2+ double-doped HA, and gelatin. In vitro cell experiments and bacterial experiments, the composite scaffolds, especially the 10%Cu-10%Sr- HA/Gel/Ti group scaffolds, have good biocompatibility and integration with bone tissues, promoting the proliferation and differentiation of BMSCs while having excellent antibacterial properties. These composite scaffolds can simultaneously achieve bone defect filling, osteoblast differentiation, and antibacterial functions, owning broad clinical application prospects.
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