亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Daily oral iron supplementation during pregnancy

医学 安慰剂 怀孕 置信区间 相对风险 分娩 临床试验 随机对照试验 儿科 缺铁 贫血 内科学 替代医学 遗传学 病理 生物
作者
M. C. Nesheim,Elvira González de Mejı́a,Therese Dowswell,Fernando E. Viteri
标识
DOI:10.1002/14651858.cd004736.pub4
摘要

Iron and folic acid supplementation has been the preferred intervention to improve iron stores and prevent anaemia among pregnant women, and it may also improve other maternal and birth outcomes.To assess the effects of daily oral iron supplements for pregnant women, either alone or in conjunction with folic acid, or with other vitamins and minerals as a public health intervention.We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (2 July 2012). We also searched the WHO International Clinical Trials Registry Platform (ICTRP) (2 July 2012) and contacted relevant organisations for the identification of ongoing and unpublished studies.Randomised or quasi-randomised trials evaluating the effects of oral preventive supplementation with daily iron, iron + folic acid or iron + other vitamins and minerals during pregnancy.We assessed the methodological quality of trials using standard Cochrane criteria. Two review authors independently assessed trial eligibility, extracted data and conducted checks for accuracy.We included 60 trials. Forty-three trials, involving more than 27,402 women, contributed data and compared the effects of daily oral supplements containing iron versus no iron or placebo.Overall, women taking iron supplements were less likely to have low birthweight newborns (below 2500 g) compared with controls (8.4% versus 10.2%, average risk ratio (RR) 0.81; 95% confidence interval (CI) 0.68 to 0.97, 11 trials, 8480 women) and mean birthweight was 30.81 g greater for those infants whose mothers received iron during pregnancy (average mean difference (MD) 30.81; 95% CI 5.94 to 55.68, 14 trials, 9385 women). Preventive iron supplementation reduced the risk of maternal anaemia at term by 70% (RR 0.30; 95% CI 0.19 to 0.46, 14 trials, 2199 women) and iron deficiency at term by 57% (RR 0.43; 95% CI 0.27 to 0.66, seven trials, 1256 women). Although the difference between groups did not reach statistical significance, women who received iron supplements were more likely than controls to report side effects (25.3% versus 9.91%) (RR 2.36; 95% CI 0.96 to 5.82, 11 trials, 4418 women), particularly at doses 60 mg of elemental iron or higher. Women receiving iron were on average more likely to have higher haemoglobin (Hb) concentrations at term and in the postpartum period, but were at increased risk of Hb concentrations greater than 130g/L during pregnancy and at term. Twenty-three studies were conducted in countries that in 2011 had some malaria risk in parts of the country. In some of these countries/territories, malaria is present only in certain areas or up to a particular altitude. Only two of these reported malaria outcomes. There is no evidence that iron supplementation increases placental malaria. For some outcomes heterogeneity was higher than 50%.Prenatal supplementation with daily iron are effective to reduce the risk of low birthweight, and to prevent maternal anaemia and iron deficiency in pregnancy. Associated maternal side effects and particularly high Hb concentrations during pregnancy at currently used doses suggest the need to update recommendations on doses and regimens for routine iron supplementation.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
畅快访蕊发布了新的文献求助10
3秒前
11秒前
11秒前
14秒前
科研通AI2S应助振羽采纳,获得10
16秒前
dogontree发布了新的文献求助10
16秒前
打打应助djbj2022采纳,获得10
26秒前
29秒前
29秒前
31秒前
远方完成签到 ,获得积分10
32秒前
顾矜应助dogontree采纳,获得10
33秒前
rita_sun1969完成签到,获得积分10
47秒前
脑洞疼应助野生菜狗采纳,获得10
48秒前
54秒前
54秒前
marceloclaro完成签到,获得积分10
54秒前
57秒前
58秒前
依唔吁发布了新的文献求助10
59秒前
cxx完成签到 ,获得积分10
1分钟前
Aira发布了新的文献求助10
1分钟前
江城一霸发布了新的文献求助30
1分钟前
健康的筝完成签到 ,获得积分10
1分钟前
医科大学菜鸡完成签到,获得积分20
1分钟前
fangjc1024发布了新的文献求助10
1分钟前
韩保晨完成签到 ,获得积分10
1分钟前
可爱的函函应助Aira采纳,获得10
1分钟前
奋斗的煎饼完成签到,获得积分10
1分钟前
JamesPei应助依唔吁采纳,获得10
1分钟前
Kirin完成签到 ,获得积分10
1分钟前
Ship完成签到,获得积分10
1分钟前
子桑南发布了新的文献求助30
1分钟前
1分钟前
fangjc1024完成签到,获得积分10
1分钟前
1分钟前
dogontree发布了新的文献求助10
1分钟前
Orange应助医科大学菜鸡采纳,获得10
1分钟前
Hello应助dogontree采纳,获得10
1分钟前
kingqjack完成签到,获得积分10
1分钟前
高分求助中
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
麻省总医院内科手册(原著第8版) (美)马克S.萨巴蒂尼 500
Chen Hansheng: China’s Last Romantic Revolutionary 500
宽禁带半导体紫外光电探测器 388
Pearson Edxecel IGCSE English Language B 300
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3142628
求助须知:如何正确求助?哪些是违规求助? 2793538
关于积分的说明 7806806
捐赠科研通 2449789
什么是DOI,文献DOI怎么找? 1303444
科研通“疑难数据库(出版商)”最低求助积分说明 626917
版权声明 601314