提拉帕扎明
光动力疗法
光敏剂
细胞毒性
化学
癌症研究
光热治疗
医学
肿瘤缺氧
单线态氧
缺氧(环境)
氧气
放射治疗
光化学
体外
生物化学
有机化学
内科学
作者
Yanyan Liu,Yong Liu,Wenbo Bu,Chao Cheng,Chuantao Zuo,Qingfeng Xiao,Yong Sun,Dalong Ni,Chen Zhang,Jianan Liu,Jianlin Shi
标识
DOI:10.1002/anie.201500478
摘要
Local hypoxia in tumors is an undesirable consequence of photodynamic therapy (PDT), which will lead to greatly reduced effectiveness of this therapy. Bioreductive pro-drugs that can be activated at low-oxygen conditions will be highly cytotoxic under hypoxia in tumors. Based on this principle, double silica-shelled upconversion nanoparticles (UCNPs) nanostructure capable of co-delivering photosensitizer (PS) molecules and a bioreductive pro-drug (tirapazamine, TPZ) were designed (TPZ-UC/PS), with which a synergetic tumor therapeutic effect has been achieved first by UC-based (UC-) PDT under normal oxygen environment, immediately followed by the induced cytotoxicity of activated TPZ when oxygen is depleted by UC-PDT. Treatment with TPZ-UC/PS plus NIR laser resulted in a remarkably suppressed tumor growth as compared to UC-PDT alone, implying that the delivered TPZ has a profound effect on treatment outcomes for the much-enhanced cytotoxicity of TPZ under PDT-induced hypoxia.
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