经颅直流电刺激
医学
脊髓损伤
脑刺激
刺激
物理医学与康复
神经调节
创伤性脑损伤
焦虑
麻醉
萧条(经济学)
随机对照试验
脊髓
心理学
外科
内科学
精神科
宏观经济学
经济
作者
Felipe Fregni,Paulo S. Boggio,Moises C. Lima,Merari J.L. Ferreira,Tim Wagner,Sergio P. Rigonatti,Anita Weigand de Castro,Daniel Rúbio de Souza,Marcelo Riberto,Steven D. Freedman,Michael A. Nitsche,Álvaro Pascual‐Leone
出处
期刊:Pain
[Ovid Technologies (Wolters Kluwer)]
日期:2006-03-28
卷期号:122 (1): 197-209
被引量:682
标识
DOI:10.1016/j.pain.2006.02.023
摘要
Past evidence has shown that motor cortical stimulation with invasive and non-invasive brain stimulation is effective to relieve central pain. Here we aimed to study the effects of another, very safe technique of non-invasive brain stimulation – transcranial direct current stimulation (tDCS) – on pain control in patients with central pain due to traumatic spinal cord injury. Patients were randomized to receive sham or active motor tDCS (2 mA, 20 min for 5 consecutive days). A blinded evaluator rated the pain using the visual analogue scale for pain, Clinician Global Impression and Patient Global Assessment. Safety was assessed with a neuropsychological battery and confounders with the evaluation of depression and anxiety changes. There was a significant pain improvement after active anodal stimulation of the motor cortex, but not after sham stimulation. These results were not confounded by depression or anxiety changes. Furthermore, cognitive performance was not significantly changed throughout the trial in both treatment groups. The results of our study suggest that this new approach of cortical stimulation can be effective to control pain in patients with spinal cord lesion. We discuss potential mechanisms for pain amelioration after tDCS, such as a secondary modulation of thalamic nuclei activity.
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