亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Skeletal muscle glucose uptake during short-term contractile activity in vivo: Effect of prior contractions

磷酸肌酸 骨骼肌 收缩(语法) 化学 内科学 糖原 葡萄糖摄取 刺激 内分泌学 肌肉收缩 体内 医学 生物 胰岛素 能量代谢 生物技术
作者
Kurt A. Mossberg,J. I. Mommessin,Heinrich Taegtmeyer
出处
期刊:Metabolism-clinical and Experimental [Elsevier BV]
卷期号:42 (12): 1609-1616 被引量:15
标识
DOI:10.1016/0026-0495(93)90158-k
摘要

The goal of the present study was to examine the time course of skeletal muscle glucose uptake and changes in intracellular metabolites occurring with the onset of in situ stimulation, and to assess the effect of a prior period of contractions on subsequent contraction-induced increases in glucose uptake. Hindlimb muscle in anesthetized rabbits was studied noninvasively using the positron-emitting glucose analog 18F-2-fluoro-deoxy-d-glucose (FDG). Fractional rates of FDG phosphorylation were measured on a minute-to-minute basis during rest, 3.5 minutes of priming exercise (PE), 15 or 30 minutes of PE recovery, and a subsequent 15-minute period of contractions. Muscles were electrically stimulated at 2 Hz, and force production was held constant during the contraction period(s). FDG uptake did not differ from control values either during PE or during 60 minutes of recovery from PE. In response to 15 minutes of contractions, muscle stimulated without PE demonstrated increased FDG uptake, but only after a delay of 5.0 ± 0.7 minutes. Muscle with PE but rested 15 minutes had increased FDG uptake with a delay of 0.5 ± 0.2 minutes, and muscle with PE but rested 30 minutes had increased FDG uptake after a delay of 8.0 ± 0.9 minutes (P < .01 all groups). All groups reached similar levels of FDG uptake by the end of 15 minutes of contractions. Both groups with PE had control levels of adenosine triphosphate (ATP), phosphocreatine (PCr), and glucose-6-phosphate (G6P) after PE recovery, but glycogen level was lower than the control value (P < .05). During the subsequent 15-minute contractile period, metabolites and glycogen demonstrated similar changes despite differences in rates of FDG uptake. In summary, we have demonstrated that (1) the kinetics of glucose uptake in contracting skeletal muscle can be quantified on a minute-to-minute basis using a positron-emitting 2-deoxyglucose tracer, (2) the early time course of glucose uptake in contracting muscle can be modified by prior contractions, and (3) uptake in the first minutes of contractile activity is determined by factors other than glycogen, G6P, PCr, and ATP.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
迷人问兰发布了新的文献求助10
18秒前
科研通AI2S应助科研通管家采纳,获得19
22秒前
sjyu1985完成签到 ,获得积分10
46秒前
闻巷雨完成签到 ,获得积分10
52秒前
pegasus0802完成签到 ,获得积分10
1分钟前
5823364完成签到,获得积分10
1分钟前
automan完成签到,获得积分10
1分钟前
天亮polar完成签到,获得积分10
1分钟前
2分钟前
2分钟前
2分钟前
朴实云应发布了新的文献求助10
2分钟前
林子青完成签到,获得积分10
3分钟前
核桃发布了新的文献求助30
3分钟前
李健应助reerwt采纳,获得10
3分钟前
3分钟前
ICSSCI发布了新的文献求助10
3分钟前
3分钟前
刘宇童给刘宇童的求助进行了留言
3分钟前
reerwt发布了新的文献求助10
3分钟前
4分钟前
科研通AI2S应助科研通管家采纳,获得10
4分钟前
科研通AI2S应助科研通管家采纳,获得10
4分钟前
ICSSCI完成签到,获得积分10
4分钟前
4分钟前
董可以发布了新的文献求助10
4分钟前
风华正茂完成签到,获得积分10
5分钟前
5分钟前
5分钟前
jimmy_bytheway完成签到,获得积分0
5分钟前
桃桃发布了新的文献求助10
5分钟前
可爱的函函应助桃桃采纳,获得10
5分钟前
5分钟前
6分钟前
6分钟前
6分钟前
NexusExplorer应助科研通管家采纳,获得10
6分钟前
所所应助爱笑的毛衣采纳,获得10
6分钟前
6分钟前
6分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990049
求助须知:如何正确求助?哪些是违规求助? 3532108
关于积分的说明 11256369
捐赠科研通 3270998
什么是DOI,文献DOI怎么找? 1805166
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809228