图表
卡托普利
基质(化学分析)
计算机科学
质量(理念)
压缩(物理)
色谱法
化学
材料科学
物理
医学
复合材料
量子力学
数据库
血压
放射科
作者
Josep Saurí,Diana Millán,Josep M. Suñé-Negre,Pilar Pérez-Lozano,Rocío Sarrate,Anna Fàbregas,Carolina Carrillo,Montserrat Miñarro Carmona,Josep R. Ticó Grau,Encarna García-Montoya
标识
DOI:10.1016/j.ijpharm.2013.11.029
摘要
The SeDeM diagram expert system has been used to study excipients, Captopril and designed formulations for their galenic characterization and to ascertain the critical points of the formula affecting product quality to obtain suitable formulations of Captopril direct compression SR matrix tablets. The application of the SeDeM diagram expert system enables selecting excipients with in order to optimize the formula in the preformulation and formulation studies. The methodology is based on the implementation of ICH Q8, establishing the design space of the formula with the use of experiment design, using the parameters of the SeDeM diagram expert system as system responses.
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