A causal role for circulating miR-34b in osteosarcoma

内科学 基因型 塔克曼 医学 基因分型 胃肠病学 SNP公司 孟德尔随机化 单核苷酸多态性 实时聚合酶链反应 分子生物学 内分泌学 生物 基因 遗传学 遗传变异
作者
Qing Tian,Jie Jia,Shiqi Ling,Ying-Ying Liu,Shiming Yang,Zengwu Shao
出处
期刊:Ejso [Elsevier BV]
卷期号:40 (1): 67-72 被引量:69
标识
DOI:10.1016/j.ejso.2013.08.024
摘要

To investigate the associations between plasma miR-34b/c expression levels and osteosarcoma (OS).A case-control study was conducted in 133 patients with OS and 133 controls. MiR-34b/c levels were detected by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) assays. Genotyping of SNP rs4938723 was done using the TaqMan assay. The causal association was examined by mendelian randomization analysis.Plasma miR-34b level was significantly lower in OS patients than in controls (P = 0.001). Expression levels of miR-34b in OS tissues decreased (P = 3.22 × 10(-4)) and was significantly related with its expression in plasma (r = 0.21, P = 0.004). Compared with wild-type TT genotype, the variant genotypes of rs4938723 TC/CC were significantly associated with increased OS risk (TC vs. TT: OR, 1.97 [95% CI: 1.40-2.55], P = 0.021; CC vs. TT: OR, 2.76 [95% CI: 2.00-3.53], P = 0.009; TC + CC vs. TT: OR, 2.16 [95% CI: 1.61-2.70], P = 0.006), consistent with its decreased effect on plasma miR-34b (TC vs. TT: -0.32 (-0.43, -0.21), P < 0.001; CC vs. TT: -0.70 (-0.84, -0.56), P < 0.001; TC + CC vs. TT: -0.42 (-0.53, -0.32), P < 0.001). Adjustment for miR-34b completely abolished the association between SNP rs4938723 and OS risk (P > 0.05). In addition, plasma expression levels of miR-34b were significantly decreased in the metastatic patients compared with that in the non-metastatic ones (P = 0.004).Plasma miR-34b was causally associated with OS risk and related with its metastatic status, suggesting that plasma miR-34b might be a novel biomarker and a potential treatment target for OS.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
852应助WIN1016采纳,获得10
刚刚
阿柒完成签到,获得积分10
刚刚
鳄鱼蛋发布了新的文献求助10
刚刚
ddd发布了新的文献求助10
刚刚
JamesPei应助传统的钧采纳,获得10
刚刚
刚刚
ding应助feiCheung采纳,获得10
刚刚
1秒前
qiu完成签到,获得积分10
1秒前
yuqinghui98发布了新的文献求助10
1秒前
yue发布了新的文献求助10
1秒前
量子星尘发布了新的文献求助10
1秒前
Lion完成签到,获得积分20
1秒前
贪玩的甜瓜完成签到,获得积分10
1秒前
漂亮孤兰完成签到 ,获得积分10
1秒前
2秒前
2秒前
大模型应助落后的哈密瓜采纳,获得10
2秒前
抛向天空完成签到,获得积分10
2秒前
lwm不想看文献完成签到 ,获得积分10
2秒前
领导范儿应助陈梦采纳,获得10
3秒前
眼睛大雨筠应助mumu采纳,获得50
3秒前
考拉发布了新的文献求助10
3秒前
YUMI发布了新的文献求助10
3秒前
噼里啪啦完成签到,获得积分10
3秒前
handsomelin完成签到,获得积分10
3秒前
keke完成签到,获得积分10
3秒前
zzll完成签到,获得积分20
3秒前
俞无声完成签到 ,获得积分10
4秒前
科比布莱恩特三世完成签到,获得积分10
4秒前
4秒前
5秒前
6秒前
搞怪大树发布了新的文献求助10
6秒前
Wwt完成签到,获得积分20
6秒前
飞飞发布了新的文献求助10
6秒前
6秒前
研友_VZG7GZ应助快乐的西装采纳,获得10
8秒前
Lion发布了新的文献求助10
8秒前
如意的幼翠完成签到 ,获得积分10
9秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969398
求助须知:如何正确求助?哪些是违规求助? 3514239
关于积分的说明 11173064
捐赠科研通 3249531
什么是DOI,文献DOI怎么找? 1794934
邀请新用户注册赠送积分活动 875501
科研通“疑难数据库(出版商)”最低求助积分说明 804827