痛觉过敏
伤害
刺激
内科学
内分泌学
(+)-纳洛酮
下丘脑
垂体切除术
内源性阿片
基础(医学)
医学
止痛药
吗啡
麻醉
化学
类阿片
受体
激素
胰岛素
作者
Catherine Vidal,Jeanne‐Marie Girault,J. Jacob
出处
期刊:Brain Research
[Elsevier]
日期:1982-02-01
卷期号:233 (1): 53-64
被引量:30
标识
DOI:10.1016/0006-8993(82)90929-5
摘要
The effects of hypophysectomy (HX) on pain regulation in basal and in various stressful situations were investigated in the rat. Pain sensitivity was assessed by measuring the thresholds of 3 nociceptive reactions (tail withdrawal, vocalization, vocalization afterdischarge) following electrical stimulation of the tail. The completeness of HX and the integrity of hypothalamus were verified in each HX rat. (1) Baseline pain thresholds were lower in HX rats than in sham-operated animals; (2) naloxone (Nx) hyperalgesia was only slightly altered by HX; (3) different types of stress induced different types of changes in nociception i.e. analgesia or hyperalgesia. The influence of HX varied according to the stress: it increased hyperalgesia, reduced analgesia, or had no effect at all. These results indicate that in the rat: (i) the pituitary participates in the regulation of basal pain sensitivity, probably through analgesic factors; (ii) Nx hyperalgesia results essentially from an antagonism of endogenous opioids originating in the CNS and not in the pituitary; and (iii) the pain regulatory processes engaged in adaptation to stressful stimuli involve the CNS and the pituitary in variable proportions depending upon the nature of the stress.
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