免疫
免疫学
结核分枝杆菌
干扰素γ
生物
肺结核
干扰素
细胞免疫
分泌物
肿瘤坏死因子α
免疫系统
医学
病理
生物化学
作者
Andrea M. Cooper,Dyana K. Dalton,Timothy A. Stewart,J P Griffin,David G. Russell,Ian M. Orme
标识
DOI:10.1084/jem.178.6.2243
摘要
The expression of protective immunity to Mycobacterium tuberculosis in mice is mediated by T lymphocytes that secrete cytokines. These molecules then mediate a variety of roles, including the activation of parasitized host macrophages, and the recruitment of other mononuclear phagocytes to the site of the infection in order to initiate granuloma formation. Among these cytokines, interferon gamma (IFN-gamma) is believed to play a key role is these events. In confirmation of this hypothesis, we show in this study that mice in which the IFN-gamma gene has been disrupted were unable to contain or control a normally sublethal dose of M. tuberculosis, delivered either intravenously or aerogenically. In such mice, a progressive and widespread tissue destruction and necrosis, associated with very high numbers of acid-fast bacilli, was observed. In contrast, despite the lack of protective immunity, some DTH-like reactivity could still be elicited. These data, therefore, indicate that although IFN-gamma may not be needed for DTH expression, it plays a pivotal and essential role in protective cellular immunity to tuberculosis infection.
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