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Predicting abdominal adipose tissue among women with familial partial lipodystrophy

生物电阻抗分析 脂肪组织 腰围 医学 磁共振成像 体质指数 皮下脂肪组织 内科学 核医学 内分泌学 放射科
作者
Tisha Joy,Brooke A. Kennedy,Salam A Al-Attar,Brian K. Rutt,Robert A. Hegele
出处
期刊:Metabolism-clinical and Experimental [Elsevier BV]
卷期号:58 (6): 828-834 被引量:18
标识
DOI:10.1016/j.metabol.2009.03.001
摘要

Abstract

The objective of the study was to determine correlations between magnetic resonance imaging (MRI) measures of truncal adiposity (trunk fat percentage [TrF %MRI], visceral adipose tissue [VAT], and subcutaneous abdominal adipose tissue [SAT]), simple clinical measures (body mass index [BMI], waist circumference [WC], and waist-to-hip ratio [WHR]), and bioelectrical impedance analysis (BIA)–derived measures (total fat percentage [TF %] and TrF %BIA) in female patients with familial partial lipodystrophy (FPLD). Our secondary aim was to generate and cross-validate predictive equations for VAT and SAT using these simple clinical and BIA-derived variables. Measures of truncal adiposity were measured using 1.5-T MRI (VAT, SAT, and TrF %MRI) and Tanita (Tokyo, Japan) 8-electrode body composition analyzer BC-418 (TrF %BIA) in 13 female FPLD patients. Pearson correlation coefficients were determined among the various adiposity parameters (BMI, WC, WHR, SAT, VAT, TrF %MRI, TrF %BIA, and TF %). Equations to estimate VAT and SAT were determined among 6 of the 13 FPLD subjects using multilinear regression analysis, and the best equations were then cross-validated in the remaining 7 subjects. Variables entered into the model included age, BMI, WC, WHR, TrF %BIA, and TF %. The TrF %MRI showed moderate correlation (r = 0.647, P = .02) with the TrF %BIA, but the discrepancy between the 2 variables increased with increasing truncal adiposity. The strongest correlate for TrF %MRI was BMI (r = 0.886, P < .0001). Visceral adipose tissue was poorly associated with simple clinical measures of BMI, WC, and WHR, but was inversely correlated with TF %, TrF %BIA, and SAT. The TF % was the strongest correlate for both SAT and VAT. Thus, the best regression equation for VAT included age, BMI, WC, and TF % (R2 = 1.0), whereas that for SAT only included TF % (R2 = 0.75). The corresponding standard error of the estimate for the predictive equations was approximately 0.03 % and 18.5 % of the mean value of VAT and SAT, respectively. In the cross-validation study, differences between predicted and observed values of SAT were larger than those of VAT. We conclude that, among female FPLD patients, (1) no simple clinical anthropometric measure correlates well with VAT, whereas BMI correlates well with SAT; (2) BIA measure of TF % most strongly correlated with both VAT and SAT; and (3) based on the cross-validation study, VAT but not SAT could be more reliably estimated using the regression equations derived.
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