生物
基因
同源(生物学)
病毒
病毒学
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爱泼斯坦-巴尔病毒
基因组
分子生物学
遗传学
细胞因子
肽序列
作者
Kevin W. Moore,Paulo Vieira,David Fiorentino,Mary Trounstine,Tariq Khan,Timothy R. Mosmann
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1990-06-08
卷期号:248 (4960): 1230-1234
被引量:1125
标识
DOI:10.1126/science.2161559
摘要
Complementary DNA clones encoding mouse cytokine synthesis inhibitory factor (CSIF; interleukin-10), which inhibits cytokine synthesis by TH1 helper T cells, were isolated and expressed. The predicted protein sequence shows extensive homology with an uncharacterized open reading frame, BCRFI, in the Epstein-Barr virus genome, suggesting the possibility that this herpes virus exploits the biological activity of a captured cytokine gene to enhance its survival in the host.
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