免疫原性
佐剂
RGD基序
肽
抗原
鼻腔给药
免疫
肽疫苗
肽序列
抗体
抗体效价
接种疫苗
病毒学
效价
生物
化学
免疫学
生物化学
表位
整合素
受体
基因
作者
Akira Yano,Atsuko Onozuka,Khairul Matin,Shoichi Imai,Nobuhiro Hanada,Tosiki Nisizawa
出处
期刊:Vaccine
[Elsevier]
日期:2003-12-01
卷期号:22 (2): 237-243
被引量:32
标识
DOI:10.1016/s0264-410x(03)00561-9
摘要
The use of peptides for various aspects of medical science has been a significant advance. Peptide-based vaccines are promising, but weak immunogenic potency is impeding the clinical application. We have remarkably enhanced the immunogenicity of peptide antigens by addition of motifs that bind to cell attachment proteins, such as arginine-glysine-aspartate (RGD), to the amino acid sequence. The modified peptides induced antigen-specific serum antibodies by intranasal immunization without adjuvants. RGD, an integrin-binding motif was the strongest, among several molecules tested in this experiment, giving an average of 10 times enhancement of antibody titers when incorporated into several peptide antigens. The peptides also acted as an efficient adjuvant following the intranasal immunization with protein antigens. Our data support the feasibility of developing peptide vaccines and peptide adjuvants for intranasal vaccination.
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