Synthesis and Cytotoxicity of Some New Substituted Hydronaphthalene Derivatives

A new series of hydronaphthalene derivatives incorporated into or fused to different five or six membered nitrogen, oxygen, sulpher, heretrocyclic, S - glycosidicor N-glycosidic moieties and other related products had been described. The hydrazine derivative 2 was coupled with bromo-sugar to achieve N -glycosides in presence of acidic medium while, the products4 and 15 were coupled with different bromo sugar achiev ing S-glycosides in presence of a basic medium. Moreover, other derivatives carrying different biologically active side chains and hetero cyclic substituents were synthesized starting with 6 -methoxy1-tetralone1. Also, theX-raydata of compound13c was studied.The cytotoxicity of some of the newly synthesized compounds was studied to evaluate their in-vitroinhibitory effects against cellular proliferation in human cultured breast carcinoma cell lines. It has been found that the chalcone derivatives 13a-cand their cyclized thiopyrimidine analogues 14a,