间充质干细胞
旁分泌信号
医学
再生医学
骨关节炎
再生(生物学)
细胞疗法
干细胞疗法
临床试验
干细胞
软骨
癌症研究
生物信息学
细胞生物学
生物
病理
内科学
解剖
替代医学
受体
作者
Feng Gao,Xinzhan Mao,Xiaoxin Wu
出处
期刊:Progress in Molecular Biology and Translational Science
日期:2023-01-01
卷期号:: 199-225
标识
DOI:10.1016/bs.pmbts.2023.02.006
摘要
Widely used for cell-based therapy in various medical fields, mesenchymal stem cells (MSCs) show capacity for anti-inflammatory effects, anti-apoptotic activity, immunomodulation, and tissue repair and regeneration. As such, they can potentially be used to treat osteoarthritis (OA). However, MSCs from different sources have distinct advantages and disadvantages, and various animal models and clinical trials using different sources of MSCs are being conducted in OA regenerative medicine. It is now widely believed that the primary tissue regeneration impact of MSCs is via paracrine effects, rather than direct differentiation and replacement. Cytokines and molecules produced by MSCs, including extracellular vesicles with mRNAs, microRNAs, and bioactive substances, play a significant role in OA repair. This chapter outlines the properties of MSCs and recent animal models and clinical trials involving MSCs-based OA therapy, as well as how the paracrine effect of MSCs acts in OA cartilage repair. Additionally, it discusses challenges and controversies in MSCs-based OA therapy. Despite its limits and unanticipated hazards, MSCs have the potential to be translated into therapeutic therapy for future OA treatment.
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