神经退行性变
部分各向异性
白质
磁共振弥散成像
内囊
生物标志物
病理
神经科学
心理学
医学
内科学
磁共振成像
疾病
化学
放射科
生物化学
作者
Thomas Welton,Yi Jayne Tan,Seyed Ehsan Saffari,Samuel Yong‐Ern Ng,Nicole Shuang Yu Chia,Alisa C.W. Yong,Xinyi Choi,Dede Liana Heng,Yang-hsin Shih,Septian Hartono,Wei-Ling Lee,Zheyu Xu,Kay Yaw Tay,Wing Lok Au,Eng‐King Tan,Ling Ling Chan,Adeline Su Lyn Ng,Louis C.S. Tan
出处
期刊:Journal of Parkinson's disease
[IOS Press]
日期:2022-10-14
卷期号:12 (7): 2135-2146
被引量:1
摘要
Neurofilament light is a marker of axonal degeneration, whose measurement from peripheral blood was recently made possible by new assays.We aimed to determine whether plasma neurofilament light chain (NfL) concentration reflects brain white matter integrity in patients with early Parkinson's disease (PD).137 early PD patients and 51 healthy controls were included. Plasma NfL levels were measured using ultrasensitive single molecule array. 3T MRI including diffusion tensor imaging was acquired for voxelwise analysis of association between NfL and both fractional anisotropy (FA) and mean diffusivity (MD) in white matter tracts and subcortical nuclei.A pattern of brain microstructural changes consistent with neurodegeneration was associated with increased plasma NfL in most of the frontal lobe and right internal capsule, with decreased FA and increased MD. The same clusters were also associated with poorer global cognition. A significant cluster in the left putamen was associated with increased NfL, with a significantly greater effect in PD than controls.Plasma NfL may be associated with brain microstructure, as measured using diffusion tensor imaging, in patients with early PD. Higher plasma NfL was associated with a frontal pattern of neurodegeneration that also correlates with cognitive performance in our cohort. This may support a future role for plasma NfL as an accessible biomarker for neurodegeneration and cognitive dysfunction in PD.
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