A new model to predict the risk of major gastrointestinal bleeding in patients on direct oral anticoagulants (dabigatran and rivaroxaban)

医学 拜瑞妥 内科学 达比加群 胃肠道出血 弗雷明翰风险评分 曲线下面积 逻辑回归 回顾性队列研究 接收机工作特性 胃肠病学 华法林 心房颤动 疾病
作者
Meina Lv,Shaojun Jiang,Ting-Ting Wu,Nianxu Huang,Xia Chen,Chunmei Chen,Jinhua Zhang
出处
期刊:British Journal of Clinical Pharmacology [Wiley]
卷期号:89 (1): 253-260 被引量:1
标识
DOI:10.1111/bcp.15491
摘要

Aims The aim of this study was to identify factors associated with gastrointestinal bleeding (GIB) in patients on direct oral anticoagulants (DOACs) and develop a risk score that would provide an effective tool for the clinical assessment of GIB. Methods This was a multicentre retrospective analysis of clinical and follow-up data of patients treated with DOACs. The score was developed through logistic regression. The performance of score was evaluated using the area under the receiver operating characteristic curve (AUC), sensitivity, specificity and Hosmer–Lemeshow test. Results The 11 903 patients had a mean age of 65.1 years. In multivariate analysis, age ≥65 years, alcohol use, history of peptic ulcer, history of major bleeding, abnormal liver function or renal function, cancer, platelet count <100 × 109/L, anaemia, and concurrent antiplatelet agent or non-steroidal anti-inflammatory drug treatment were independent risk factors for GIB, and concurrent treatment with gastrointestinal protective agents were a protective factor. The Alfalfa-DOAC-GIB score was constructed using these 12 factors. The AUC of the Alfalfa-DOAC-GIB score was 0.77 (95% CI 0.74–0.81), which was higher than that of the HAS-BLED score (0.69; 95% CI 0.65–0.72) and the New score (0.65; 95% CI 0.61–0.68). Conclusions Based on 12 factors, we developed a gastrointestinal bleeding risk score. The newly developed Alfalfa-DOAC-GIB score has better predictive value than the HAS-BLED score and the New score, and might be an effective tool to help reduce the occurrence of GIB in patients using DOACs.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
科目三应助彭栋采纳,获得10
刚刚
方文浩发布了新的文献求助10
刚刚
ding应助YWang采纳,获得10
3秒前
3秒前
林宝雯关注了科研通微信公众号
8秒前
11秒前
斯文败类应助GGBOND采纳,获得10
11秒前
星辰大海应助科研通管家采纳,获得10
11秒前
李健的小迷弟应助GGBOND采纳,获得10
11秒前
上官若男应助科研通管家采纳,获得10
11秒前
12秒前
大模型应助科研通管家采纳,获得10
12秒前
圆锥香蕉应助科研通管家采纳,获得20
12秒前
星辰大海应助科研通管家采纳,获得10
12秒前
12秒前
12秒前
Bio应助科研通管家采纳,获得30
12秒前
科研通AI5应助科研通管家采纳,获得10
12秒前
斯文败类应助科研通管家采纳,获得10
12秒前
汉堡包应助科研通管家采纳,获得10
12秒前
13秒前
16秒前
18秒前
18秒前
Dotson发布了新的文献求助10
19秒前
sinsinsin发布了新的文献求助10
20秒前
CodeCraft应助娇气的天亦采纳,获得10
21秒前
22秒前
权思远发布了新的文献求助10
22秒前
彭栋发布了新的文献求助10
22秒前
量子星尘发布了新的文献求助10
23秒前
李爱国应助收集快乐采纳,获得10
24秒前
守墓人完成签到 ,获得积分10
25秒前
26秒前
科研通AI5应助xiaoxiao采纳,获得10
29秒前
顾矜应助权思远采纳,获得10
29秒前
苯氮小羊完成签到,获得积分10
29秒前
31秒前
31秒前
34秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989115
求助须知:如何正确求助?哪些是违规求助? 3531367
关于积分的说明 11253688
捐赠科研通 3269986
什么是DOI,文献DOI怎么找? 1804868
邀请新用户注册赠送积分活动 882078
科研通“疑难数据库(出版商)”最低求助积分说明 809105