Association of blood lead exposure with frailty and its components among the Chinese oldest old

四分位数 医学 虚弱指数 逻辑回归 老年学 血铅水平 铅暴露 队列研究 队列 虚弱综合征 人口学 置信区间 内科学 社会学
作者
Yuan Wei,Jinhui Zhou,Feng Zhao,Chen Chen,Jun Wang,Yufei Luo,Chenfeng Li,Jiahui Xiong,Yuebin Lv,Juan Li,Xiaoming Shi
出处
期刊:Ecotoxicology and Environmental Safety [Elsevier BV]
卷期号:242: 113959-113959
标识
DOI:10.1016/j.ecoenv.2022.113959
摘要

Lead (Pb) is a widespread environmental contaminant, associated with a higher risk of functional impairment that can lead to frailty in older adults. However, few studies focused on the association of Pb exposure with frailty among the oldest old (aged ≥ 80 years). In this study, we aimed to assess the associations of Pb with frailty and its components in the oldest old. The included individuals were the oldest old aged ≥ 80 years who participated in a 2017 cross-sectional survey of the Healthy Aging and Biomarkers Cohort Study. Frailty was ascertained by the frailty index, which was created based on health deficits. We used logistic regression models to estimate the association of blood Pb with frailty and its components. The geometric mean and median of blood Pb were 38.51 μg/L and 36.27 μg/L among the oldest old, respectively. Compared with the first quartile of blood Pb, participants in the fourth quartile had higher risk of frailty and its components, the ORs are 1.71 (1.22–2.41), 1.99 (1.35–2.94), 1.91 (1.25–2.93), 1.57 (1.13–2.17) and 1.43 (1.05–1.96), for frailty, ADL disability, IADL disability, functional limitations, and hearing loss in the oldest old, respectively. There was a significant interaction between blood Pb and frailty in different age groups. In conclusion, our findings provide preliminary evidence that higher blood Pb may increase the risk of frailty among the oldest old by increasing the risk of disability in four physical functions: disability in ADL, disability in IADL, functional limitations, and hearing loss.
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