Imaging factors affecting prenatal counselling in orofacial clefts

<b><i>Introduction:</i></b> We aim to correlate pre- and postnatal data regarding the cleft type and surgical prognostic factors associated to orofacial clefts. <b><i>Methods:</i></b> Retrospective study concerning all cases of orofacial cleft evaluated prenatally (US+/−MRI) between 2015 and 2020 with available postnatal outcomes. We compared prenatal imaging (cleft type and surgical prognostic factors) with postnatal findings. <b><i>Results:</i></b> 48 fetuses were included. Median gestational age at first US/MRI examination: 29+2 WG and 31+6 WG, respectively. The prenatal diagnosis was in accordance with postnatal findings with regard to the cleft type in 88% of the cases (<i>n</i> = 42/48) for US and/or MRI, 84% (<i>n</i> = 38/45) for US only, and 90% (<i>n</i> = 37/41) for MRI only. The nasal septum deviation and nostril collapse were underestimated by prenatal US in 48% (<i>n</i> = 12/25) and 44% (<i>n</i> = 11/25) of cases, respectively (Cohen’s kappa of 0.22 and 0.32, respectively). Pre- and postnatal examinations were in accordance with 75% of cases (<i>n</i> = 8) regarding evaluation of anteroposterior maxillary shift in case of unilateral alveolar cleft and in 90% and 80% of cases (<i>n</i> = 10) regarding the degree of protrusion/deviation of the premaxillary protrusion in case of bilateral cleft, respectively. <b><i>Conclusion:</i></b> Prenatal imaging can accurately assess the type of orofacial cleft and evaluate maxillary shift and deviation of the premaxilla. It underestimates the nose deformity.