Permeable electronics are promising in improving the wearing comfort but still fail in dealing with the sweating issue. Herein, we develop a flexible and breathable dual-mode pressure-temperature sensor with sweat adsorption and evaporation capability. The device is constructed on a bilayer thermoplastic polyurethane (TPU)/polyacrylonitrile (PAN) nanofiber mat through electrospinning, where the PAN nanofibers are hydrophilic for sweat adsorption, while the TPU nanofibers are hydrophobic to block sweat invasion into the sensing structure. The diffused sweat evaporates into moisture, which then passes through the internal fabric microchannels across the whole substrate, ensuring excellent permeability. Besides, the pressure sensing based on a planar intronic supercapacitor and the temperature sensing based on a serpentine resistor work with no crosstalk between the two. Practical applications of the developed sensing textile for continuous monitoring of wrist pulse beating and skin temperature with unique sweat absorption and evaporation capability for dry skin status are well demonstrated. This work will boost the development of next-generation permeable electronics for wearable healthcare management with extreme comfort.