Letter by Teng et al Regarding Article, “Gut Microbiota–Derived Trimethylamine N-Oxide Contributes to Abdominal Aortic Aneurysm Through Inflammatory and Apoptotic Mechanisms”

HomeCirculationVol. 148, No. 8Letter by Teng et al Regarding Article, “Gut Microbiota–Derived Trimethylamine N-Oxide Contributes to Abdominal Aortic Aneurysm Through Inflammatory and Apoptotic Mechanisms” No AccessLetterRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessLetterRequest AccessFull TextLetter by Teng et al Regarding Article, “Gut Microbiota–Derived Trimethylamine N-Oxide Contributes to Abdominal Aortic Aneurysm Through Inflammatory and Apoptotic Mechanisms” Zhenqing Teng, Xiang Ma and Yitong Ma Zhenqing TengZhenqing Teng https://orcid.org/0000-0003-0228-7212 Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, People’s Republic of China. Search for more papers by this author , Xiang MaXiang Ma https://orcid.org/0000-0001-6528-3599 Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, People’s Republic of China. *X. Ma and Y. Ma contributed equally. Search for more papers by this author and Yitong MaYitong Ma Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, People’s Republic of China. *X. Ma and Y. Ma contributed equally. Search for more papers by this author Originally published21 Aug 2023https://doi.org/10.1161/CIRCULATIONAHA.123.065557Circulation. 2023;148:701–702"Letter by Teng et al Regarding Article, “Gut Microbiota–Derived Trimethylamine N-Oxide Contributes to Abdominal Aortic Aneurysm Through Inflammatory and Apoptotic Mechanisms”." Circulation, 148(8), pp. 701–702Footnotes*X. Ma and Y. Ma contributed equally.Circulation is available at www.ahajournals.org/journal/circREFERENCES1. Benson TW, Conrad KA, Li XS, Wang Z, Helsley RN, Schugar RC, Coughlin TM, Wadding-Lee C, Fleifil S, Russell HM, et al. Gut microbiota–derived trimethylamine N-oxide contributes to abdominal aortic aneurysm through inflammatory and apoptotic mechanisms.Circulation. 2023; 147:1079–1096. doi: 10.1161/CIRCULATIONAHA.122.060573LinkGoogle Scholar2. Chen S, Henderson A, Petriello MC, Romano KA, Gearing M, Miao J, Schell M, Sandoval-Espinola WJ, Tao J, Sha B, et al. Trimethylamine N-oxide binds and activates PERK to promote metabolic dysfunction.Cell Metab. 2019; 30:1141–1151.e5. doi: 10.1016/j.cmet.2019.08.021CrossrefMedlineGoogle Scholar3. Tian Z, Zhang Y, Zheng Z, Zhang M, Zhang T, Jin J, Zhang X, Yao G, Kong D, Zhang C, et al. Gut Microbiome dysbiosis contributes to abdominal aortic aneurysm by promoting neutrophil extracellular trap formation.Cell Host Microbe. 2022; 30:1450–1463.e8. doi: 10.1016/j.chom.2022.09.004CrossrefMedlineGoogle Scholar4. Ren J, Bi Y, Sowers JR, Hetz C, Zhang Y. Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases.Nat Rev Cardiol. 2021; 18:499–521. doi: 10.1038/s41569-021-00511-wCrossrefMedlineGoogle Scholar5. Luo W, Wang Y, Zhang L, Ren P, Zhang C, Li Y, Azares AR, Zhang M, Guo J, Ghaghada KB, et al. Critical role of cytosolic DNA and its sensing adaptor STING in aortic degeneration, dissection, and rupture.Circulation. 2020; 141:42–66. doi: 10.1161/CIRCULATIONAHA.119.041460LinkGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate.Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page.Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetails August 22, 2023Vol 148, Issue 8 Advertisement Article InformationMetrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCULATIONAHA.123.065557PMID: 37603602 Originally publishedAugust 21, 2023 PDF download Advertisement SubjectsAneurysmEthics and PolicyVascular Disease