化脓性汗腺炎
转录组
免疫系统
生物
上皮
脱颗粒
病理生理学
基因表达谱
病理
趋化因子
先天免疫系统
免疫学
白细胞介素8
炎症
医学
基因
基因表达
疾病
遗传学
受体
作者
Christine Suh-Yun Joh,Soyoung Jeong,Chul Lee,Hee Jung Lee,Jung Ho Lee,Hyun Seung Choi,Soyun Cho,Gwangil Kim,Jaehwan Kim,James G. Krueger,Chung‐Gyu Park,Jung U Shin,Seon‐Pil Jin,Hyun Je Kim
摘要
We investigated the role of the epithelium of nodules in Hurley stage I hidradenitis suppurativa (HS) by using spatial transcriptomics to analyse the profiles of epithelial cells and dermal-infiltrating immune cells. Compared with epidermal cysts, genes related to bacterial response, inflammatory mediators and neutrophil degranulation pathways were upregulated in the epithelial cells of early-stage HS nodules. Our analysis of dermal-infiltrating immune cells surrounding the epithelium of nodules revealed significantly elevated levels of B-cell-related genes. Similarly to the sinus tract formation observed in moderate-to-severe HS, we propose that the production of inflammatory mediators in early-stage HS may involve the activation of keratinocytes and their interaction with dermal-infiltrating immune cells.
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