医学
气管切除术
宫颈癌
阶段(地层学)
保持生育能力
产科
回顾性队列研究
外科
生育率
癌症
妇科
人口
内科学
古生物学
环境卫生
生物
作者
Kathrin Siegler,Andrea Plaikner,Hermann Hertel,Kati Hasenbein,Anja Petzel,Melanie Schubert,Jens‐Uwe Blohmer,Gerd Böhmer,Simone Marnitz,V. Ragosch,Christian Domröse,Peter Oppelt,Anne Jülicher,Achim Schneider,Anne Willems,Giovanni Favero,Christhardt Köhler
标识
DOI:10.1016/j.jmig.2023.11.006
摘要
ABSTRACT
Study Objective
This study aimed to present our case series of patients with early-stage cervical cancer undergoing simple trachelectomy (ST). Currently, radical trachelectomy is considered the most appropriate fertility-preserving procedure for the treatment of early-stage cervical cancer. However, there is increasing debate on the appropriate radicality of the surgery to preserve oncologic safety. Design
Descriptive retrospective analysis of patient records and evaluation of questionnaires. Setting
2 gynecologic oncologic centers, surgeries performed by one surgical team. Patients
36 women with early-stage cervical cancer undergoing ST. Interventions
Laparoscopic assisted simple vaginal trachelectomy. Measurements
Demographic, histologic, fertility, and follow-up data of all patients who underwent ST between April 2007 and July 2021 were prospectively recorded and retrospectively analyzed. Main Results
A total of 36 women (mean age: 28 years) underwent ST of whom 81% were nulliparous. Indications for ST were multifocal International Federation of Gynecology and Obstetrics stage IA1 (n = 30), stage IA1 L1 (n = 1), stage IA2 (n = 2), and stage IB1 (n = 3). Mandatory staging procedure was laparoscopic pelvic lymphadenectomy, including bilateral sentinel biopsy in 92% of the cases and systematic in 8%. Residual tumor was histologically confirmed in 8 specimens (22%); 18 women (50%) were seeking parenthood, and 13 succeeded (72%). There were 16 live births, all on term, with a median fetal weight of 3110 grams (2330–4420). One patient had a medical abortion owing to fetal congenital malformation. One pregnancy is ongoing. After a median follow-up of 91.5 months (9–174), all women are alive with no evidence of disease. Conclusion
ST represents a de-escalation compared with radical trachelectomy and provides excellent oncologic results with an outstanding fertility rate and obstetric outcome for patients with early cervical cancer. However, clear indications for this tailored fertility-preserving surgery have to be defined in well-designed trials.
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