Hepatic soluble epoxide hydrolase: A promising target for unveiling the liver-brain axis in Alzheimer’s disease

Wu and Dong et al. 1 Wu Y. Dong J.H. Dai Y.F. Zhu M.Z. Wang M.Y. Zhang Y. Pan Y.D. Yuan X.R. Guo Z.X. Wang C.X. et al. Hepatic soluble epoxide hydrolase activity regulates cerebral Abeta metabolism and the pathogenesis of Alzheimer's disease in mice. Neuron. 2023; 111: 2847-2862https://doi.org/10.1016/j.neuron.2023.06.002 Abstract Full Text Full Text PDF Scopus (9) Google Scholar report that hepatic soluble epoxide hydrolase (sEH) manipulation impacts amyloid-β (Aβ) deposits and cognitive impairment in mouse models for Alzheimer's disease (AD), suggesting that hepatic sEH activity is a promising therapeutic target to treat AD. Wu and Dong et al. 1 Wu Y. Dong J.H. Dai Y.F. Zhu M.Z. Wang M.Y. Zhang Y. Pan Y.D. Yuan X.R. Guo Z.X. Wang C.X. et al. Hepatic soluble epoxide hydrolase activity regulates cerebral Abeta metabolism and the pathogenesis of Alzheimer's disease in mice. Neuron. 2023; 111: 2847-2862https://doi.org/10.1016/j.neuron.2023.06.002 Abstract Full Text Full Text PDF Scopus (9) Google Scholar report that hepatic soluble epoxide hydrolase (sEH) manipulation impacts amyloid-β (Aβ) deposits and cognitive impairment in mouse models for Alzheimer's disease (AD), suggesting that hepatic sEH activity is a promising therapeutic target to treat AD.