肠易激综合征
医学
炎症性肠病
便秘
恶化
肠道菌群
疾病
胃肠病学
表观基因组
机制(生物学)
免疫系统
内科学
免疫学
生物
DNA甲基化
生物化学
基因表达
哲学
认识论
基因
作者
Chaolan Lv,Gengqing Song,Deyong Xiao,Wei Wang,Yizhou Huang,Bo Wang,Junjian Tian,Min Yin,Yue Yu
标识
DOI:10.3748/wjg.v29.i41.5657
摘要
Inflammatory bowel disease (IBD) has as a main characteristic the exacerbation of the immune system against enterocytes, compromising the individual’s intestinal microbiota. This inflammatory cascade causes several nutritional deficiencies, which further compromise immunological functioning and, as a result, worsen the prognosis. This vicious cycle can be interrupted as the patient’s dietary pattern meets their needs according to their clinical condition, acting directly on the inflammatory process of IBD through the interaction of food, intestinal microbiota, and epigenome. Specific nutritional intervention for IBD has a crucial role in preventing and managing disease activity. This review addresses epigenetic modifications through dietary compounds as a mechanism for modulating the intestinal microbiota of patients with IBD.
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