Progress on lysosomal PPT1-mediated regulation of cellular homeostasis and pathogenesis.

Palmitoyl protein thioesterase 1(PPT1) is a lysosomal enzyme that catalyzes the protein depalmitoylation. It is considered to play a crucial role in regulating lysosomes, mitochondria and lipid metabolism. PPT1 has been reported to play an important role in the occurrence and progression of diseases, such as neurological diseases and cancers. However, the regulatory mechanisms remain unknown. In this review, we summarize the progress of PPT1 function and mechanisms in neurological disorders and cancers, which will provide as reference and guidance for exploring the regulatory mechanisms of PPT1 and developing new drugs for treating related diseases in the future.棕榈酰蛋白质硫酯酶1 (palmitoyl protein thioesterase 1，PPT1)是一种溶酶体酶，具有对蛋白质行使去棕榈酰化修饰的功能，在调控细胞器(如溶酶体、线粒体)功能、脂质代谢和Ca2+转运等方面具有重要作用。PPT1在神经系统疾病和癌症的发生发展中发挥了重要的作用，然而其调控作用机制仍未被完全阐明。本文综述了目前PPT1在脂质代谢调控、物质转运调控、钙稳态调控过程中的作用及最新研究进展，总结并探讨了PPT1在神经系统疾病及肿瘤发生发展中作用及调控机制，为将来更深层次研究PPT1的功能及调控机制并开发相关疾病治疗的新药物提供借鉴和参考。.