重编程
脂质代谢
表观遗传学
生物
癌变
癌症
转移
癌细胞
代谢途径
癌症研究
生物信息学
计算生物学
细胞
遗传学
生物化学
新陈代谢
基因
作者
Shanshan Liu,Benzheng Jiao,Hongguang Zhao,Xinyue Liang,Fengyan Jin,Xiaodong Liu,Ji‐Fan Hu
标识
DOI:10.1002/advs.202303570
摘要
As one of novel hallmarks of cancer, lipid metabolic reprogramming has recently been becoming fascinating and widely studied. Lipid metabolic reprogramming in cancer is shown to support carcinogenesis, progression, distal metastasis, and chemotherapy resistance by generating ATP, biosynthesizing macromolecules, and maintaining appropriate redox status. Notably, increasing evidence confirms that lipid metabolic reprogramming is under the control of dysregulated non-coding RNAs in cancer, especially lncRNAs and circRNAs. This review highlights the present research findings on the aberrantly expressed lncRNAs and circRNAs involved in the lipid metabolic reprogramming of cancer. Emphasis is placed on their regulatory targets in lipid metabolic reprogramming and associated mechanisms, including the clinical relevance in cancer through lipid metabolism modulation. Such insights will be pivotal in identifying new theranostic targets and treatment strategies for cancer patients afflicted with lipid metabolic reprogramming.
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