刺
信号转导
神经科学
生物
医学
细胞生物学
工程类
航空航天工程
作者
Kun Yang,Zhen Tang,Cong Xing,Nan Yan
出处
期刊:Neuron
[Elsevier]
日期:2023-11-08
卷期号:112 (4): 539-557
被引量:6
标识
DOI:10.1016/j.neuron.2023.10.014
摘要
SummaryStimulator of interferon genes (STING) is an innate immune signaling protein critical to infections, autoimmunity, and cancer. STING signaling is also emerging as an exciting and integral part of many neurological diseases. Here, we discuss recent advances in STING signaling in the brain. We summarize how molecular threats activate STING signaling in the diseased brain and how STING signaling activities in glial and neuronal cells cause neuropathology. We also review human studies of STING neurobiology and consider therapeutic challenges in targeting STING to treat neurological diseases.
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