Recent progress on chiral extractants for enantioselective liquid-liquid extraction

As the demand for enantiopure compounds increases, chiral separation has become increasingly important in many fields. Enantioselective liquid-liquid extraction is an up-and-coming technology for enantiomeric separation because it is highly efficient and easy to be scaled up. The key factor for enantioselective liquid-liquid extraction is the development of novel chiral extractants with high enantiorecognition performance. With successful studies on catalytically active metal complexes as chiral extractants, novel chiral extractants can be screened and designed from the field of asymmetric catalysis. Chiral ionic liquids, sulfobutylether-β-cyclodextrins bonded magnetic nanoparticles and 2,2′,3,3′-tetrahydro-1,1′-spirobi[indene]-7,7′-diol (SPINOL) based phosphoric acid host show unique potential ability in enantioselective liquid-liquid extraction and they deserve further study. Brief principles, extraction equipment and solvent systems in enantioselective liquid-liquid extraction are presented in the present paper, and recent progress in development of new chiral extractants in the past decade is mainly reviewed, including metal complexes, cyclodextrins, ionic liquids, tartrate acids and crown ethers.