Solid phase extraction technology combined with UPLC-MS/MS: a method for detecting 20 β-lactamase antibiotics traces in goat's milk

We develop and validate a method for the rapid determination and identification of 20 β-lactamase antibiotics traces in goat's milk by combining the solid phase extraction technology with ultra-high performance liquid chromatography-tandem mass spectrometry. Goat milk samples were extracted with acetonitrile twice. The supernatant was then extracted and cleaned by solid-phase extraction using divinylbenzene and