Resurgence of morphology: Discarded small cell lung carcinoma subtypes reflect current molecular classification

Pathology InternationalEarly View LETTER TO THE EDITOR Resurgence of morphology: Discarded small cell lung carcinoma subtypes reflect current molecular classification Hironori Ninomiya, Hironori Ninomiya orcid.org/0009-0004-6814-8471 Division of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan Department of Pathology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, JapanSearch for more papers by this author Hironori Ninomiya, Hironori Ninomiya orcid.org/0009-0004-6814-8471 Division of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan Department of Pathology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, JapanSearch for more papers by this author First published: 18 June 2024 https://doi.org/10.1111/pin.13460Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. REFERENCES 1Rudin CM, Poirier JT, Byers LA, Dive C, Dowlati A, George J, et al. Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data. Nat Rev Cancer. 2019 May; 19(5): 289–297. 10.1038/s41568-019-0133-9 CASPubMedWeb of Science®Google Scholar 2Jimbo N, Ohbayashi C, Takeda M, Fujii T, Mitsui S, Tsukamoto R, et al. POU2F3-expressing small cell lung carcinoma and large cell neuroendocrine carcinoma show morphologic and phenotypic overlap. Am J Surg Pathol. 2024 Jan 1; 48(1): 4–15. 10.1097/PAS.0000000000002145 PubMedGoogle Scholar 3Qu S, Fetsch P, Thomas A, Pommier Y, Schrump DS, Miettinen MM, et al. Molecular subtypes of primary SCLC tumors and their associations with neuroendocrine and therapeutic markers. J Thorac Oncol. 2022 Jan; 17(1): 141–153. 10.1016/j.jtho.2021.08.763 CASPubMedWeb of Science®Google Scholar 4Huang YH, Klingbeil O, He XY, Wu XS, Arun G, Lu B, et al. POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer. Genes Dev. 2018 Jul 1; 32(13–14): 915–928. 10.1101/gad.314815.118 CASPubMedWeb of Science®Google Scholar 5Ireland AS, Micinski AM, Kastner DW, Guo B, Wait SJ, Spainhower KB, et al. MYC drives temporal evolution of small cell lung cancer subtypes by reprogramming neuroendocrine fate. Cancer Cell. 2020 Jul 13; 38(1): 60–78.e12. 10.1016/j.ccell.2020.05.001 CASPubMedWeb of Science®Google Scholar Early ViewOnline Version of Record before inclusion in an issue ReferencesRelatedInformation