脚手架
生物材料
血管内皮生长因子受体
小岛
3d打印
糖尿病
医学
化学
癌症研究
生物医学工程
内分泌学
作者
Xuchun Chen,Kangchun Wang,Zhi Yang,Qi Pan,Xinrui Jiang,Zitong Yu,Weichen Zhang,Ziqi Wang,Haomin Yan,Ping Sun,Jingjing Liang,Heran Li,Ying Cheng
标识
DOI:10.1016/j.ijbiomac.2024.132376
摘要
Diabetes is a complex metabolic disease and islet transplantation is a promising approach for the treatment of diabetes. Unfortunately, the transplanted islets at the subcutaneous site are also affected by various adverse factors such as poor vascularization and hypoxia. In this study, we utilize biocompatible copolymers l-lactide and D,l-lactide to manufacture a biomaterial scaffold with a mesh-like structure via 3D printing technology, providing a material foundation for encapsulating pancreatic islet cells. The scaffold maintains the sustained release of vascular endothelial growth factor (VEGF) and a slow release of oxygen from calcium peroxide (CPO), thereby regulating the microenvironment for islet survival. This helps to improve insufficient subcutaneous vascularization and reduce islet death due to hypoxia post-transplantation. By pre-implanting VEGF-CPO scaffolds subcutaneously into diabetic rats, a sufficiently vascularized site is formed, thereby ensuring early survival of transplanted islets. In a word, the VEGF-CPO scaffold shows good biocompatibility both in vitro and in vivo, avoids the adverse effects on the implanted islets, and displays promising clinical transformation prospects.
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