A transparent, environmentally friendly and durable superhydrophobic coating preparation process was developed to effectively isolate water molecules in the air, aiming to reduce the use limitations of the wood-based panel substrate and to realize its improved performance in terms of water resistance, stain resistance and durability. This study employs a coating method to apply a silica sol-modified nanocellulose (CNF) and polyvinyl alcohol (PVA) solution onto a wood-based panel substrate, creating a micro-nano rough structure. Subsequently, the vapor deposition method was employed to functionalize the silanol groups on the coating surface, resulting in the formation of fluorinated alkyl groups and achieving transparent superhydrophobic wood-based panels. The water contact angle measures 152.6°, the rolling angle was 4.5°, and the coating exhibits a light transmittance of 92%. Notably, the superhydrophobicity of the coating persists even after repeated polishing paper abrasion, demonstrating excellent anti-pollution self-cleaning properties. This study is of great significance for the long-term use of wood-based panels indoors and outdoors, as well as their application in complex and high humidity environments.