启动(农业)
材料科学
肿瘤微环境
细胞
癌症研究
生物物理学
细胞生物学
纳米技术
肿瘤细胞
生物
生物化学
植物
发芽
作者
Tan Li,Gengjia Chen,Liteng Lin,Bo Li,Xiaobin Wang,Ye Chen,Wensou Huang,Mingyue Cai,Zecong Xiao,Xintao Shuai,Kangshun Zhu
出处
期刊:Biomaterials
[Elsevier]
日期:2024-09-01
卷期号:309: 122626-122626
标识
DOI:10.1016/j.biomaterials.2024.122626
摘要
The development of manganese oxide-based chemodynamic immunotherapy is emerging as a key strategy against solid tumors. However, the limited efficacy of nanoplatform in inducing efficient tumor therapeutic effects and creating the prominent antitumor immune responses remains a crucial issue. In this study, we construct a novel multifunctional biomimetic nanovaccine comprising manganese oxide-loaded poly(2-diisopropylaminoethyl methacrylate) (MP) nanoparticles and a coating layer of hybrid cell membrane (RHM) derived from manganese oxide-remodeled 4T1 cells and dendritic cells (DCs) (collectively called MP@RHM) for combination chemodynamic immunotherapy. Compared with the nanovaccines coated with the single cell membrane, the MP@RHM nanovaccine highly efficiently activates both DCs and T cells to boost tumor-specific T cell, owing to the synergistic effects of abundant damage-associated molecular patterns, Mn
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