真菌
聚酮
预酸化
立体化学
萜类
圆二色性
海洋真菌
乙酰化
化学
六边形
二维核磁共振波谱
细胞毒性
生物合成
生物
生物化学
植物
酶
体外
基因
作者
Ling-Zhi Tang,Jin‐Mei Xia,Zhongwei Chen,Xiaohui Wu,Guangyu Li,Qiliang Lai,Zongze Shao,Weiyi Wang,Xuan Hong
出处
期刊:Marine Drugs
[MDPI AG]
日期:2024-06-13
卷期号:22 (6): 274-274
摘要
Talaromyces, a filamentous fungus widely distributed across terrestrial and marine environments, can produce a diverse array of natural products, including alkaloids, polyketones, and polyketide-terpenoids. Among these, chrodrimanins represented a typical class of natural products. In this study, we isolated three previously undescribed pentaketide-sesquiterpenes, 8,9-epi-chrodrimanins (1–3), along with eight known compounds (4–11). The structures of compounds 1–3 were elucidated using nuclear magnetic resonance (NMR) and mass spectrometry (MS), while their absolute configurations were determined through X-ray crystallography and electronic circular dichroism (ECD) computations. The biosynthetic pathways of compounds 1–3 initiate with 6-hydroxymellein and involve multiple stages of isoprenylation, cyclization, oxidation, and acetylation. We selected four strains of gastrointestinal cancer cells for activity evaluation. We found that compound 3 selectively inhibited MKN-45, whereas compounds 1 and 2 exhibited no significant inhibitory activity against the four cell lines. These findings suggested that 8,9-epi-chrodrimanins could serve as scaffold compounds for further structural modifications, potentially leading to the development of targeted therapies for gastric cancer.
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