Iron-Catalyzed Three-Component Asymmetric Carboazidation of Alkenes with Alkanes and TMSN3

The fusion of transition metal catalysis with radical chemistry provides a versatile platform for the asymmetric radical carboazidation of alkenes to enable a rapid assembly of highly functionalized chiral azine compounds. Here, we present an iron-catalyzed asymmetric three-component radical carboazidation that processes electron-deficient alkenes by direct activation of aliphatic C-H bonds. This strategy allows to access a range of valuable chiral azine compounds from readily available chemical feedstocks, bearing a tetrasubstituted carbon stereocenter, and their synthetic potential is further showcased through straightforward transformations to provide other valuable enantioenriched building blocks.