Pain chronification impacts whole-brain functional connectivity in women with hip osteoarthritis during pain stimulation

补品(生理学) 骨关节炎 医学 冷压试验 伤害 脑电图 慢性疼痛 功能连接 神经影像学 神经科学 物理医学与康复 麻醉 心理学 物理疗法 内科学 病理 心率 替代医学 受体 血压
作者
Joachim Erlenwein,Joachim Erlenwein,Mikkel Gram,Deborah Falla,Asbjørn Mohr Drewes,Michael Przemeck,Frank Petzke
出处
期刊:Pain Medicine [Oxford University Press]
卷期号:24 (9): 1073-1085 被引量:1
标识
DOI:10.1093/pm/pnad057
摘要

Abstract Objective Previous neuroimaging studies have shown that patients with chronic pain display altered functional connectivity across distributed brain areas involved in the processing of nociceptive stimuli. The aim of the present study was to investigate how pain chronification modulates whole-brain functional connectivity during evoked clinical and tonic pain. Methods Patients with osteoarthritis of the hip (n = 87) were classified into 3 stages of pain chronification (Grades I–III, Mainz Pain Staging System). Electroencephalograms were recorded during 3 conditions: baseline, evoked clinical hip pain, and tonic cold pain (cold pressor test). The effects of both factors (recording condition and pain chronification stage) on the phase-lag index, as a measure of neuronal connectivity, were examined for different frequency bands. Results In women, we found increasing functional connectivity in the low-frequency range (delta, 0.5–4 Hz) across pain chronification stages during evoked clinical hip pain and tonic cold pain stimulation. In men, elevated functional connectivity in the delta frequency range was observed in only the tonic cold pain condition. Conclusions Across pain chronification stages, we found that widespread cortical networks increase their synchronization of delta oscillations in response to clinical and experimental nociceptive stimuli. In view of previous studies relating delta oscillations to salience detection and other basic motivational processes, our results hint at these mechanisms playing an important role in pain chronification, mainly in women.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
欣喜踏歌发布了新的文献求助10
1秒前
1秒前
1秒前
1秒前
1秒前
1秒前
1秒前
1秒前
1秒前
紧张的谷槐完成签到,获得积分10
1秒前
麋鹿发布了新的文献求助10
2秒前
领导范儿应助zzz采纳,获得10
2秒前
dyhiaefhv完成签到,获得积分10
3秒前
3秒前
3秒前
山丘完成签到,获得积分10
4秒前
5秒前
chongya1发布了新的文献求助10
6秒前
请风来守完成签到,获得积分10
6秒前
Starrism发布了新的文献求助10
6秒前
jim_hacker发布了新的文献求助10
6秒前
王大大完成签到,获得积分10
6秒前
虚拟的惜筠完成签到,获得积分10
6秒前
5433发布了新的文献求助10
6秒前
7秒前
offred完成签到,获得积分10
7秒前
pwy完成签到,获得积分10
7秒前
在水一方应助小荇采纳,获得10
8秒前
8秒前
郑昕玥发布了新的文献求助10
9秒前
9秒前
李可汗发布了新的文献求助10
10秒前
10秒前
麋鹿完成签到,获得积分10
11秒前
11秒前
阳佟半仙发布了新的文献求助10
11秒前
严溯发布了新的文献求助10
11秒前
yyy完成签到 ,获得积分10
12秒前
12秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968934
求助须知:如何正确求助?哪些是违规求助? 3513835
关于积分的说明 11170238
捐赠科研通 3249167
什么是DOI,文献DOI怎么找? 1794650
邀请新用户注册赠送积分活动 875278
科研通“疑难数据库(出版商)”最低求助积分说明 804755